The search for longevity and renewed quality of life is as old as mankind. Ancient Greek and Roman physicians used plant and animal products to attempt to slow or turn back the clock. Aristotle referred to age at menopause being 40 years. Juan Ponce de Leon, born in 1474, sailed to the New World in search of the fountain of youth. Hormone Replacement Therapy extends back to at least the eleventh century A.D. Written records indicate that Chinese physicians used dried crystalized urine from teenage girls to help aging women counteract the symptoms associated with menopause and promote longer, more productive and vigorous lives. Eating animal glands to promote youthfulness and longevity has long been advocated in various cultures for many hundreds of years in the past and is still practiced in some parts of the world today.